Research

My research focuses on emergency radiology, AI applications in medical imaging, and neuroradiology. I collaborate with the neuroimaging and AI research group at the University of Turku and Turku University Hospital. You can also find my work on Google Scholar.

Doctoral dissertation

Nyman, M. (2019). Visualization and Quantification of Neurokinin-1 Receptors in Human Brain With Positron Emission Tomography. Doctoral dissertation, University of Turku. Annales Universitatis Turkuensis, Sarja D 1435. ISBN 978-951-29-7704-8.

Publications

2026

Elo, A., Vierula, J.-P., Heikkinen, J., Nurminen, J., Happonen, T., Nyman, M., Velhonoja, J., Irjala, H., Soukka, T., Mattila, K., Arponen, O., Siren, A., & Hirvonen, J. (2026). MRI-based measurement of masseter muscle area: reliability and clinical relevance in acute neck infections. European Radiology.

Viertonen, V. S., Siren, A., Nyman, M., Huhtanen, H., Klen, R., Hirvonen, J., & Rainio, O. (2026). Acute deep neck infection MRI: deep learning segmentation and clinical relevance of retropharyngeal edema volume. European Radiology Experimental, 10(1), 15.

Misin, O., Piispanen, A., Matilainen, M., Parkkola, R., Nyman, M., Sainio, T., Hirvonen, J., & Airas, L. (2026). Real-world detection of paramagnetic rim lesions and their association with disease burden in multiple sclerosis. Multiple Sclerosis and Related Disorders, 107, 107012.

2025

Vierula, J.-P., Aro, K., Bode, M., Haapio, E., Hakumaki, J., Happonen, T., Hollmen, C., Huhtanen, H., Irjala, H., Jouppila-Matto, A., Nyman, M., et al. (2025). MRI edema patterns in acute neck infections: A multicenter and multidisciplinary interobserver study. European Journal of Radiology, 112526.

Kresanov, P., Nyman, M., Parkkola, R., Pirila, L., Ryyppo, L., & Taimen, K. (2025). Utility of cranial and cervical vessel magnetic resonance imaging as a diagnostic aid in a patient with suspected giant cell arteritis. Scandinavian Journal of Rheumatology, 1-3.

Rainio, O., Huhtanen, H., Vierula, J.-P., Nurminen, J., Heikkinen, J., Nyman, M., Klen, R., & Hirvonen, J. (2025). Deep learning detects retropharyngeal edema on MRI in patients with acute neck infections. European Radiology Experimental, 9(1), 60.

Huhtanen, J. T., Nyman, M., Blanco Sequeiros, R., Koskinen, S. K., Pudas, T. K., Kajander, S., Niemi, P., Aronen, H. J., & Hirvonen, J. (2025). Comparative accuracy of two commercial AI algorithms for musculoskeletal trauma detection in emergency radiographs. Emergency Radiology, 1-12.

Huhtanen, J. T., Nyman, M., Sequeiros, R. B., Koskinen, S. K., Pudas, T. K., Kajander, S., Niemi, P., Loyttyniemi, E., Aronen, H. J., & Hirvonen, J. (2025). Discrepancies between Radiology Specialists and Residents in Fracture Detection from Musculoskeletal Radiographs (vol 13, 3207, 2023) - Correction. Diagnostics, 15(1), 3.

Vierula, J-P, Merisaari, H, Heikkinen, J, Happonen, T, Siren, A, Velhonoja, J, Irjala, H, Soukka, T, Mattila, K, Nyman, M, Hirvonen, J (2025). MRI-based risk factors for intensive care unit admissions in acute neck infections. European Journal of Radiology Open, 14, 100648.

Huhtanen, H. J., Nyman, M. J., Karlsson, A., & Hirvonen, J. (2025). Machine Learning and Deep Learning Models for Automated Protocoling of Emergency Brain MRI Using Text from Clinical Referrals. Radiology: Artificial Intelligence, 7(3), e230620.

2024

Huhtanen, J. T., Nyman, M., Sequeiros, R. B., Koskinen, S. K., Pudas, T. K., Kajander, S., Niemi, P., Loyttyniemi, E., Aronen, H. J., & Hirvonen, J. (2024). Correction: Huhtanen et al. Discrepancies between Radiology Specialists and Residents in Fracture Detection from Musculoskeletal Radiographs. Diagnostics 2023, 13, 3207. Diagnostics, 15(1), 3.

Siren, A., Turkia, E., Nyman, M., & Hirvonen, J. (2024). Accuracy of Intra-Axial Brain Tumor Characterization in the Emergency MRI Reports: A Retrospective Human Performance Benchmarking Pilot Study. Diagnostics, 14(16), 1791.

Siren, A., Nyman, M., Syvanen, J., Mattila, K., & Hirvonen, J. (2024). Imaging Outcomes of MRI After CT in Pediatric Spinal Trauma: A Single-Center Experience. Journal of Pediatric Orthopaedics, 44(10), e887-93.

Happonen, T., Nyman, M., Ylikotila, P., Mattila, K., & Hirvonen, J. (2024). Imaging Outcomes of Emergency MR Imaging in Dizziness and Vertigo: A Retrospective Cohort Study. AJNR. American Journal of Neuroradiology.

Siren, A., Nyman, M., Syvanen, J., Mattila, K., & Hirvonen, J. (2024). Utility of brain imaging in pediatric patients with a suspected accidental spinal injury but no brain injury-related symptoms. Child's Nervous System, 40(5), 1435-1441.

Siren, A., Syvanen, J., Nyman, M., Mattila, K., & Hirvonen, J. (2024). Outcomes of Follow-up Imaging After Pediatric Spinal Trauma Confirmed With Magnetic Resonance Imaging. Journal of Pediatric Orthopedics.

2023

Kantonen, O., Laaksonen, L., Alkire, M., Scheinin, A., Langsjo, J., Kallionpaa, R. E., Kaisti, K., Radek, L., Johansson, J., Laitio, T., Maksimow, A., Scheinin, J., Nyman, M., Scheinin, M., Solin, O., Vahlberg, T., Revonsuo, A., Valli, K., & Scheinin, H. (2023). Decreased Thalamic Activity Is a Correlate for Disconnectedness during Anesthesia with Propofol, Dexmedetomidine and Sevoflurane But Not S-Ketamine. Journal of Neuroscience, 43(26), 4884-4895.

Huhtanen, J. T., Nyman, M., Sequeiros, R. B., Koskinen, S. K., Pudas, T. K., Kajander, S., Niemi, P., Loyttyniemi, E., Aronen, H. J., & Hirvonen, J. Discrepancies between Radiology Specialists and Residents in Fracture Detection from Musculoskeletal Radiographs. Diagnostics 13, no. 20 (January 2023): 3207.

Vierula, J.-P., Nurminen, J., Jussila, V., Nyman, M., Heikkinen, J., Pape, B., Sorvettula, K., Mattila, K., & Hirvonen, J. Diagnostic Performance of Short Noncontrast Biparametric 3-T MRI for Tonsillar Infections: Comparison with a Full Protocol Including Contrast-Enhanced Sequences. European Radiology Experimental 7, no. 1 (October 24, 2023): 65.

Siren, A., Nyman, M., Syvanen, J., Mattila, K., & Hirvonen, J. (2023). Clinical outcome following magnetic resonance imaging as first-line imaging in low-impact pediatric spine trauma: a single-center retrospective observational study. Pediatric Radiology.

Nurminen, J., Heikkinen, J., Happonen, T., Nyman, M., Siren, A., Vierula, J.-P., Velhonoja, J., Irjala, H., Soukka, T., Ivaska, L., Mattila, K., & Hirvonen, J. (2023). Pictorial Review of MRI Findings in Acute Neck Infections in Children. Children, 10(6), 967.

Hirvonen, J., & Nyman, M. (2023). Ostaisinko radiologista tekoalya sairaalaan-mita asiasta pitaa tietaa? Duodecim; Laaketieteellinen Aikakauskirja, 139(6), 421-423.

Siren, A., Nyman, M., Syvanen, J., Mattila, K., & Hirvonen, J. (2023). Emergency MRI in spine trauma of children and adolescents-A pictorial review. Children, 10(7).

2022

Poyhonen, H. M., Nyman, M. J., Peltola, V. T., Loyttyniemi, E. S., & Lahdesmaki, T. T. (2022). Neuroimaging and neurological outcome of children with acute encephalitis. Developmental Medicine & Child Neurology, 64(10), 1262-1269.

Huhtanen, J. T., Nyman, M., Doncenco, D., Hamedian, M., Kawalya, D., Salminen, L., Sequeiros, R. B., Koskinen, S. K., Pudas, T. K., Kajander, S., Niemi, P., Hirvonen, J., Aronen, H. J., & Jafaritadi, M. (2022). Deep learning accurately classifies elbow joint effusion in adult and pediatric radiographs. Scientific Reports, 12, 11803.

Heikkinen, J., Nurminen, J., Velhonoja, J., Irjala, H., Soukka, T., Happonen, T., Nyman, M., Mattila, K., & Hirvonen, J. (2022). MRI Findings in Acute Tonsillar Infections. American Journal of Neuroradiology, 43(2), 286-291.

Huhtanen, H., Nyman, M., Mohsen, T., Virkki, A., Karlsson, A., & Hirvonen, J. (2022). Automated detection of pulmonary embolism from CT-angiograms using deep learning. BMC Medical Imaging, 22(1), 43.

2021

Scheinin, A., Kantonen, O., Alkire, M., Langsjo, J., Kallionpaa, R. E., Kaisti, K., Radek, L., Johansson, J., Sandman, N., Nyman, M., Scheinin, M., Vahlberg, T., Revonsuo, A., Valli, K., & Scheinin, H. (2021). Foundations of Human Consciousness: Imaging the Twilight Zone. Journal of Neuroscience, 41(8), 1769-1778.

Nurminen, J., Velhonoja, J., Heikkinen, J., Happonen, T., Nyman, M., Irjala, H., Soukka, T., Mattila, K., & Hirvonen, J. (2021). Emergency neck MRI: feasibility and diagnostic accuracy in cases of neck infection. Acta Radiologica, 62(6), 735-742.

Poyhonen, H., Setanen, S., Isaksson, N., Nyman, M., Nyman, A., Peltola, V., & Lahdesmaki, T. (2021). Neurological and Cognitive Performance After Childhood Encephalitis. Frontiers in Pediatrics, 9, 646684.

2020

Rebelos, E., Hirvonen, J., Bucci, M., Pekkarinen, L., Nyman, M., Hannukainen, J. C., Iozzo, P., Salminen, P., Nummenmaa, L., Ferrannini, E., & Nuutila, P. (2020). Brain free fatty acid uptake is elevated in morbid obesity. Diabetes, Obesity and Metabolism, 22(7), 1074-1082.

Nazari-Farsani, S., Nyman, M., Karjalainen, T., Bucci, M., Isojarvi, J., & Nummenmaa, L. (2020). Automated segmentation of acute stroke lesions using a data-driven anomaly detection on diffusion weighted MRI. Journal of Neuroscience Methods, 333, 108575.

Huhtanen, H., Nyman, M., Karlsson, A., & Hirvonen, J. (2020). Tekoaly radiologiassa. Duodecim, 136(17), 1957-1964.

2019

Nyman, M., Eskola, O., Kajander, J., Jokinen, R., Penttinen, J., Karjalainen, T., Nummenmaa, L., Hirvonen, J., Burns, D., Hargreaves, R., Solin, O., & Hietala, J. (2019). Brain neurokinin-1 receptor availability in never-medicated patients with major depression - A pilot study. Journal of Affective Disorders, 242, 188-194.

Laurikainen, H., Isotupa, I., Nyman, M., Ilonen, T., Nummelin, T., Salokangas, R. K. R., & Hietala, J. (2019). Longitudinal brain morphology in anti-NMDA receptor encephalitis: a case report with controls. BMC Psychiatry, 19(1), 145.

2018

Laaksonen, L., Kallioinen, M., Langsjo, J., Laitio, T., Scheinin, A., Scheinin, J., Kaisti, K., Maksimow, A., Kallionpaa, R. E., Rajala, V., Johansson, J., Kantonen, O., Nyman, M., Siren, S., Valli, K., Revonsuo, A., Solin, O., Vahlberg, T., Alkire, M., & Scheinin, H. (2018). Comparative effects of dexmedetomidine, propofol, sevoflurane, and S-ketamine on regional cerebral glucose metabolism in humans: a positron emission tomography study. British Journal of Anaesthesia, 121(1), 281-290.

2016

Vanninen, R., Putaala, J., Bode, M., Nyman, M., Pekkola, J., & Manninen, H. (2016). Akuutin aivohalvauspotilaan kuvantaminen valtimotukoksen hoidon suunnittelussa. Duodecim, 132(21), 1973-1982.

Jalava-Karvinen, P., Nyman, M., Gardberg, M., Harju, I., Hohenthal, U., & Oksi, J. (2016). Scedosporium apiospermum as a rare cause of central skull base osteomyelitis. Medical Mycology Case Reports, 11, 28-30.

2008

Huttunen, J., Heinimaa, M., Svirskis, T., Nyman, M., Kajander, J., Forsback, S., Solin, O., Ilonen, T., Korkeila, J., Ristkari, T., McGlashan, T., Salokangas, R. K., & Hietala, J. (2008). Striatal dopamine synthesis in first-degree relatives of patients with schizophrenia. Biological Psychiatry, 63(1), 114-117.

2007

Wallius, E., Nyman, M., Oikonen, V., Hietala, J., & Ruotsalainen, U. (2007). Voxel-based NK1 receptor occupancy measurements with [18F]SPA-RQ and positron emission tomography: a procedure for assessing errors from image reconstruction and physiological modeling. Molecular Imaging and Biology, 9(5), 284-294.

Koikkalainen, J., Hirvonen, J., Nyman, M., Lotjonen, J., Hietala, J., & Ruotsalainen, U. (2007). Shape variability of the human striatum--Effects of age and gender. NeuroImage, 34(1), 85-93.

Nyman, M. J., Eskola, O., Kajander, J., Vahlberg, T., Sanabria, S., Burns, D., Hargreaves, R., Solin, O., & Hietala, J. (2007). Gender and age affect NK1 receptors in the human brain - a positron emission tomography study with [18F]SPA-RQ. International Journal of Neuropsychopharmacology, 10(2), 219-229.

2006

Hietanen, J. K., Nummenmaa, L., Nyman, M. J., Parkkola, R., & Hamalainen, H. (2006). Automatic attention orienting by social and symbolic cues activates different neural networks: an fMRI study. NeuroImage, 33(1), 406-413.

2005

Hietala, J., Nyman, M. J., Eskola, O., Laakso, A., Gronroos, T., Oikonen, V., Bergman, J., Haaparanta, M., Forsback, S., Marjamaki, P., Lehikoinen, P., Goldberg, M., Burns, D., Hamill, T., Eng, W. S., Coimbra, A., Hargreaves, R., & Solin, O. (2005). Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain. Molecular Imaging and Biology, 7(4), 262-272.